Semaglutide & Tirzepatide Dosing Guide - GLP-1 Weight Loss Peptides

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What Are GLP-1 Agonists?

GLP-1 (glucagon-like peptide-1) agonists are a class of medications originally developed for type 2 diabetes that have shown remarkable efficacy for weight management. They work by mimicking the natural GLP-1 hormone produced in your gut after eating.

Semaglutide is the active ingredient in Ozempic and Wegovy. Tirzepatide is the active ingredient in Mounjaro and Zepbound. While semaglutide targets only the GLP-1 receptor, tirzepatide is a dual agonist that also targets the GIP receptor.

Semaglutide Titration Schedule

Titration 1: 0.25 mg weekly for 4 weeks. Titration 2: 0.5 mg for 4 weeks. Titration 3: 1.0 mg for 4 weeks. Titration 4: 1.7 mg for 4 weeks. Maintenance: 2.4 mg ongoing.

Tirzepatide Titration Schedule

Starting: 2.5 mg for 4 weeks. Then 5.0 mg, 7.5 mg, 10.0 mg, 12.5 mg (each for 4 weeks). Maximum: 15.0 mg ongoing.

Managing Side Effects

Nausea

• Eat smaller, more frequent meals
• Avoid greasy, fried, or heavy foods
• Stay hydrated

Constipation

• Increase fiber intake gradually
• Drink at least 64oz of water daily
• Light exercise promotes gut motility

Use our calculator for precise Semaglutide and Tirzepatide dosing.

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