MK-677 vs Ipamorelin
A detailed side-by-side comparison of MK-677 and Ipamorelin covering dosing, storage, research findings, and practical usage.
Overview
MK-677: An orally active GH secretagogue that increases IGF-1 and GH levels.
Ipamorelin: A selective GH secretagogue with minimal effect on cortisol or prolactin.
Comparison Table
| Property | MK-677 | Ipamorelin |
|---|---|---|
| Category | Growth Hormone Secretagogue | Growth Hormone Secretagogue |
| Typical Dose | 10000-25000 mcg | 100-300 mcg |
| Frequency | 1x daily | 2-3x daily |
| Half-Life | ~24 hours | 2-3 hours |
| Timing | Evening or before bed | Morning fasted, post-workout, and before bed (fasted 2+ hours) |
Ipamorelin Research
Ipamorelin is a synthetic pentapeptide that acts as a selective growth hormone secretagogue. Unlike other GHRPs, ipamorelin specifically stimulates growth hormone release without significantly affecting cortisol, prolactin, or aldosterone levels, making it one of the cleanest GH-releasing peptides available. Research shows it provides a controlled, dose-dependent GH pulse similar to natural secretion patterns. Studies demonstrate benefits for body composition, sleep quality, and recovery. Ipamorelin is often combined with CJC-1295 (no DAC) for synergistic effects, as they work through complementary pathways (GHRP + GHRH).
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For laboratory research use only. Not for human consumption.